Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins

We and others have clearly demonstrated that a topoisomerase I (Top1) inhibitor, such as camptothecin (CPT), coupled to a triplex-forming oligonucleotide (TFO) through a suitable linker can be used to cause site-specific cleavage of the targeted DNA sequence in in vitro models. Here we evaluated whe...

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Detalhes bibliográficos
Main Authors: Oussedik, Kahina, François, Jean-Christophe, Halby, Ludovic, Senamaud-Beaufort, Catherine, Toutirais, Géraldine, Dallavalle, Sabrina, Pommier, Yves, Pisano, Claudio, Arimondo, Paola B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887256/
https://ncbi.nlm.nih.gov/pubmed/20179147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-132324
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