Tyrosine Phosphorylation of Phosphoinositide-Dependent Kinase 1 by the Insulin Receptor Is Necessary for Insulin Metabolic Signaling

In L6 myoblasts, insulin receptors with deletion of the C-terminal 43 amino acids (IR(Δ43)) exhibited normal autophosphorylation and IRS-1/2 tyrosine phosphorylation. The L6 cells expressing IR(Δ43) (L6(IRΔ43)) also showed no insulin effect on glucose uptake and glycogen synthase, accompanied by a &...

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Main Authors: Fiory, Francesca, Alberobello, Anna Teresa, Miele, Claudia, Oriente, Francesco, Esposito, Iolanda, Corbo, Vincenzo, Ruvo, Menotti, Tizzano, Barbara, Rasmussen, Thomas E., Gammeltoft, Steen, Formisano, Pietro, Beguinot, Francesco
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316974/
https://ncbi.nlm.nih.gov/pubmed/16314505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.10803-10814.2005
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