In Skeletal Muscle Advanced Glycation End Products (AGEs) Inhibit Insulin Action and Induce the Formation of Multimolecular Complexes Including the Receptor for AGEs

Chronic hyperglycemia promotes insulin resistance at least in part by increasing the formation of advanced glycation end products (AGEs). We have previously shown that in L6 myotubes human glycated albumin (HGA) induces insulin resistance by activating protein kinase Cα (PKCα). Here we show that HGA...

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Detalhes bibliográficos
Main Authors: Cassese, Angela, Esposito, Iolanda, Fiory, Francesca, Barbagallo, Alessia P. M., Paturzo, Flora, Mirra, Paola, Ulianich, Luca, Giacco, Ferdinando, Iadicicco, Claudia, Lombardi, Angela, Oriente, Francesco, Van Obberghen, Emmanuel, Beguinot, Francesco, Formisano, Pietro, Miele, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662288/
https://ncbi.nlm.nih.gov/pubmed/18955497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801698200
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