In Skeletal Muscle Advanced Glycation End Products (AGEs) Inhibit Insulin Action and Induce the Formation of Multimolecular Complexes Including the Receptor for AGEs

Chronic hyperglycemia promotes insulin resistance at least in part by increasing the formation of advanced glycation end products (AGEs). We have previously shown that in L6 myotubes human glycated albumin (HGA) induces insulin resistance by activating protein kinase Cα (PKCα). Here we show that HGA...

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Hlavní autoři: Cassese, Angela, Esposito, Iolanda, Fiory, Francesca, Barbagallo, Alessia P. M., Paturzo, Flora, Mirra, Paola, Ulianich, Luca, Giacco, Ferdinando, Iadicicco, Claudia, Lombardi, Angela, Oriente, Francesco, Van Obberghen, Emmanuel, Beguinot, Francesco, Formisano, Pietro, Miele, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662288/
https://ncbi.nlm.nih.gov/pubmed/18955497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801698200
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