Molecular Cloning and Characterization of the Human PED/PEA-15 Gene Promoter Reveal Antagonistic Regulation by Hepatocyte Nuclear Factor 4α and Chicken Ovalbumin Upstream Promoter Transcription Factor II

Overexpression of the ped/pea-15 gene in mice impairs glucose tolerance and leads to diabetes in conjunction with high fat diet treatment. PED/PEA-15 is also overexpressed in type 2 diabetics as well as in euglycemic offspring from these subjects. The cause(s) of this abnormality remains unclear. In...

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Autori principali: Ungaro, Paola, Teperino, Raffaele, Mirra, Paola, Cassese, Angela, Fiory, Francesca, Perruolo, Giuseppe, Miele, Claudia, Laakso, Markku, Formisano, Pietro, Beguinot, Francesco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Transcription, Chromatin, and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662169/
https://ncbi.nlm.nih.gov/pubmed/18765665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803895200
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