Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death

Insulin-like growth factor-1 (IGF-1) signaling system exerts a broad antiapoptotic function and plays a crucial role in resistance to anticancer therapies. Exposure of MCF-7 breast cancer cells to IGF-1 rapidly and transiently induced tyrosine phosphorylation and activation of phosphoinositide-depen...

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Bibliografiska uppgifter
Huvudupphovsmän: Alberobello, A. Teresa, D'Esposito, Vittoria, Marasco, Daniela, Doti, Nunzianna, Ruvo, Menotti, Bianco, Roberto, Tortora, Giampaolo, Esposito, Iolanda, Fiory, Francesca, Miele, Claudia, Beguinot, Francesco, Formisano, Pietro
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825452/
https://ncbi.nlm.nih.gov/pubmed/20044479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.097410
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