Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase α (CCTα)

Farnesol (FOH) inhibits the CDP-choline pathway for PtdCho (phosphatidylcholine) synthesis, an activity that is involved in subsequent induction of apoptosis. Interestingly, the rate-limiting enzyme in this pathway, CCTα (CTP:phosphocholine cytidylyltransferase α), is rapidly activated, cleaved by c...

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Bibliografiska uppgifter
Huvudupphovsmän: Lagace, Thomas A., Ridgway, Neale D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2005
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316283/
https://ncbi.nlm.nih.gov/pubmed/16097951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051021
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