Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486

Human papillomaviruses (HPVs) are the causative agents of benign and malignant lesions of the epithelium. Despite their high prevalence, there is currently no antiviral drug for the treatment of HPV-induced lesions. The ATPase and helicase activities of the highly conserved E1 protein of HPV are ess...

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Bibliografiset tiedot
Päätekijät: White, Peter W., Faucher, Anne-Marie, Massariol, Marie-Josée, Welchner, Ewald, Rancourt, Jean, Cartier, Mireille, Archambault, Jacques
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2005
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315966/
https://ncbi.nlm.nih.gov/pubmed/16304143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.4834-4842.2005
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