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Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486

Human papillomaviruses (HPVs) are the causative agents of benign and malignant lesions of the epithelium. Despite their high prevalence, there is currently no antiviral drug for the treatment of HPV-induced lesions. The ATPase and helicase activities of the highly conserved E1 protein of HPV are ess...

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Main Authors: White, Peter W., Faucher, Anne-Marie, Massariol, Marie-Josée, Welchner, Ewald, Rancourt, Jean, Cartier, Mireille, Archambault, Jacques
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315966/
https://ncbi.nlm.nih.gov/pubmed/16304143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.4834-4842.2005
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