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A rotary pumping model for helicase function of MCM proteins at a distance from replication forks

We propose an integrated model for eukaryotic DNA replication to explain the following problems: (1) How is DNA spooled through fixed sites of replication? (2) What and where are the helicases that unwind replicating DNA? (3) Why are the best candidates for replicative helicases, namely mini-chromos...

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Detalhes bibliográficos
Main Authors: Laskey, Ronald A., Madine, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315806/
https://ncbi.nlm.nih.gov/pubmed/12524516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor706
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