Slicer function of Drosophila Argonautes and its involvement in RISC formation

Argonaute proteins play important yet distinct roles in RNA silencing. Human Argonaute2 (hAgo2) was shown to be responsible for target RNA cleavage (“Slicer”) activity in RNA interference (RNAi), whereas other Argonaute subfamily members do not exhibit the Slicer activity in humans. In Drosophila, A...

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Bibliographic Details
Main Authors: Miyoshi, Keita, Tsukumo, Hiroko, Nagami, Tomoko, Siomi, Haruhiko, Siomi, Mikiko C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315391/
https://ncbi.nlm.nih.gov/pubmed/16287716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1370605
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