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Slicer function of Drosophila Argonautes and its involvement in RISC formation

Argonaute proteins play important yet distinct roles in RNA silencing. Human Argonaute2 (hAgo2) was shown to be responsible for target RNA cleavage (“Slicer”) activity in RNA interference (RNAi), whereas other Argonaute subfamily members do not exhibit the Slicer activity in humans. In Drosophila, A...

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Detalhes bibliográficos
Main Authors: Miyoshi, Keita, Tsukumo, Hiroko, Nagami, Tomoko, Siomi, Haruhiko, Siomi, Mikiko C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315391/
https://ncbi.nlm.nih.gov/pubmed/16287716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1370605
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