The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells

Signal transducer and activator of transcription 5 (STAT5) is constitutively activated by BCR/ABL, the oncogenic tyrosine kinase responsible for chronic myelogenous leukemia. The mechanism of BCR/ABL-mediated STAT5 activation is unknown. We show here that the BCR/ABL SH3 and SH2 domains interact wit...

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Détails bibliographiques

Publié dans:	EMBO J
Auteurs principaux:	Klejman, Agata, Schreiner, Steven J., Nieborowska-Skorska, Malgorzata, Slupianek, Artur, Wilson, Matthew, Smithgall, Thomas E., Skorski, Tomasz
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2002
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC131059/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12411494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf562
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