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Distinct involvement of the Jun-N-terminal kinase and NF-κB pathways in the repression of the human COL1A2 gene by TNF-α
We used a gene knockout approach to elucidate the specific roles played by the Jun-N-terminal kinase (JNK) and NF-κB pathways downstream of TNF-α in the context of α(2) type I collagen gene (COL1A2) expression. In JNK(1)(−/−)-JNK(2)(−/−) (JNK(−/−)) fibroblasts, TNF-α inhibited basal COL1A2 expressio...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1307596/ https://ncbi.nlm.nih.gov/pubmed/12393755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf219 |
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