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Combining chemical genetics and proteomics to identify protein kinase substrates

Phosphorylation is a ubiquitous protein modification important for regulating nearly every aspect of cellular biology. Protein kinases are highly conserved and constitute one of the largest gene families. Identifying the substrates of a kinase is essential for understanding its cellular role, but do...

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Detalhes bibliográficos
Main Authors: Dephoure, Noah, Howson, Russell W., Blethrow, Justin D., Shokat, Kevan M., O'Shea, Erin K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1306798/
https://ncbi.nlm.nih.gov/pubmed/16330754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509080102
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