Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Overexpression of the transmembrane receptor tyrosine kinase ErbB2 is common in multiple malignancies, including breast and ovarian cancer. ErbB2 is resistant to degradation mediated by c-Cbl, the E3 ubiquitin ligase responsible for ligand-induced ubiquitination of ErbB1 (epidermal growth factor rec...

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Main Authors: Xu, Wanping, Marcu, Monica, Yuan, Xitong, Mimnaugh, Edward, Patterson, Cam, Neckers, Len
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC130548/
https://ncbi.nlm.nih.gov/pubmed/12239347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202365899
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