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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

This paper describes insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SCAP (SREBP cleavage-activating protein) in a sterol-regulated fashion, thus preventing it from escorting SREBPs to the Golgi. B...

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Bibliografiske detaljer
Main Authors: Yabe, Daisuke, Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130532/
https://ncbi.nlm.nih.gov/pubmed/12242332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162488899
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