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β-Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

Previous work showed that human β-globin mRNAs harboring a premature termination codon are degraded in the erythroid tissues of mice to products that lack sequences from the mRNA 5′ end but contain a 5′ cap-like structure. Whether these decay products are the consequence of endonucleolytic or 5′-to-...

Täydet tiedot

Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Stevens, Audrey, Wang, Yang, Bremer, Kirsten, Zhang, Jing, Hoepfner, Robert, Antoniou, Michael, Schoenberg, Daniel R., Maquat, Lynne E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2002
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130530/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242335/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192442399
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