β-Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

Previous work showed that human β-globin mRNAs harboring a premature termination codon are degraded in the erythroid tissues of mice to products that lack sequences from the mRNA 5′ end but contain a 5′ cap-like structure. Whether these decay products are the consequence of endonucleolytic or 5′-to-...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Stevens, Audrey, Wang, Yang, Bremer, Kirsten, Zhang, Jing, Hoepfner, Robert, Antoniou, Michael, Schoenberg, Daniel R., Maquat, Lynne E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130530/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192442399
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