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The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR; cholesterol-lowering)- and sterol regulatory element-binding protein (SREBP; cholesterol-raising)-mediated signaling pathways. Previously we reported that the hypocholesterolemic agent LY295427 (4α-allylcholestan-3α-ol) rever...
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
2002
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130519/ https://ncbi.nlm.nih.gov/pubmed/12242342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202471599 |
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