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Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis
Cellular cholesterol levels are controlled by endoplasmic reticulum (ER) sterol sensing proteins, which include Scap and Insig-1. With cholesterol sufficiency, Insig inhibits the activation of sterol regulatory element binding proteins (SREBPs), key transcription factors for cholesterol and fatty ac...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824017/ https://ncbi.nlm.nih.gov/pubmed/24217618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201305076 |
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