Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis

Cellular cholesterol levels are controlled by endoplasmic reticulum (ER) sterol sensing proteins, which include Scap and Insig-1. With cholesterol sufficiency, Insig inhibits the activation of sterol regulatory element binding proteins (SREBPs), key transcription factors for cholesterol and fatty ac...

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Bibliographic Details
Main Authors: Huber, Michael D., Vesely, Paul W., Datta, Kaustuv, Gerace, Larry
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824017/
https://ncbi.nlm.nih.gov/pubmed/24217618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201305076
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