Distinct Effects on Ca(2+) Handling Caused by Malignant Hyperthermia and Central Core Disease Mutations in RyR1

Malignant hyperthermia (MH) and central core disease (CCD) are disorders of skeletal muscle Ca(2+) homeostasis that are linked to mutations in the type 1 ryanodine receptor (RyR1). Certain RyR1 mutations result in an MH-selective phenotype (MH-only), whereas others result in a mixed phenotype (MH +...

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Bibliographic Details
Main Authors: Dirksen, Robert T., Avila, Guillermo
Format: Artigo
Language:Inglês
Published: Biophysical Society 2004
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304789/
https://ncbi.nlm.nih.gov/pubmed/15347586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.048447
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