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In Silico Activation of KcsA K(+) Channel by Lateral Forces Applied to the C-Termini of Inner Helices

Crystallographic studies of K(+) channels in the closed (KcsA) and open (MthK) states suggest that Gly(99) (KcsA numbering) in the inner helices serves as a gating hinge during channel activation. However, some P-loop channels have larger residues in the corresponding position. The comparison of x-r...

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Main Authors: Tikhonov, Denis B., Zhorov, Boris S.
格式: Artigo
語言:Inglês
出版: Biophysical Society 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304559/
https://ncbi.nlm.nih.gov/pubmed/15345533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.103.037770
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