Formation Pathways of a Guanine-Quadruplex DNA Revealed by Molecular Dynamics and Thermodynamic Analysis of the Substates

The formation of a cation-stabilized guanine quadruplex (G-DNA) stem is an exceptionally slow process involving complex kinetics that has not yet been characterized at atomic resolution. Here, we investigate the formation of a parallel stranded G-DNA stem consisting of four strands of d(GGGG) using...

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Autores principales: Štefl, Richard, Cheatham, Thomas E., Špačková, Nad'a, Fadrná, Eva, Berger, Imre, Koča, Jaroslav, Šponer, Jiří
Formato: Artigo
Lenguaje:Inglês
Publicado: Biophysical Society 2003
Materias:
Nucleic Acids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303352/
https://ncbi.nlm.nih.gov/pubmed/12944293
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