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Untangling Ligand Induced Activation and Desensitization of G-Protein–Coupled Receptors
Long-term treatment with a drug to a G-protein–coupled receptor (GPCR) often leads to receptor-mediated desensitization, limiting the therapeutic lifetime of the drug. To better understand how this therapeutic window might be controlled, we created a mechanistic Monte Carlo model of the early steps...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Biophysical Society
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1302589/ https://ncbi.nlm.nih.gov/pubmed/12524261 |
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