Loading...

Untangling Ligand Induced Activation and Desensitization of G-Protein–Coupled Receptors

Long-term treatment with a drug to a G-protein–coupled receptor (GPCR) often leads to receptor-mediated desensitization, limiting the therapeutic lifetime of the drug. To better understand how this therapeutic window might be controlled, we created a mechanistic Monte Carlo model of the early steps...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Woolf, Peter J., Linderman, Jennifer J.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302589/
https://ncbi.nlm.nih.gov/pubmed/12524261
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!