Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.

The weaver mutation (G156S) in G-protein-gated inwardly rectifying K+ (GIRK) channels alters ion selectivity and reveals sensitivity to inhibition by a charged local anesthetic, QX-314, applied extracellularly. In this paper, disrupting the ion selectivity in another GIRK channel, chimera I1G1(M), g...

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Glavni avtor: Slesinger, P A
Format: Artigo
Jezik:Inglês
Izdano: 2001
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301269/
https://ncbi.nlm.nih.gov/pubmed/11159438
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