Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels.

Mutations in segment IVS6 of voltage-gated Na(+) channels affect fast-inactivation, slow-inactivation, local anesthetic action, and batrachotoxin (BTX) action. To detect conformational changes associated with these processes, we substituted a cysteine for a valine at position 1583 in the rat adult s...

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Bibliographic Details
Main Authors: Vedantham, V, Cannon, S C
Format: Artigo
Language:Inglês
Published: 2000
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300879/
https://ncbi.nlm.nih.gov/pubmed/10827974
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