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The Position of the Fast-Inactivation Gate during Lidocaine Block of Voltage-gated Na(+) Channels
Lidocaine produces voltage- and use-dependent inhibition of voltage-gated Na(+) channels through preferential binding to channel conformations that are normally populated at depolarized potentials and by slowing the rate of Na(+) channel repriming after depolarizations. It has been proposed that the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2222985/ https://ncbi.nlm.nih.gov/pubmed/9874684 |
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