Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1.

A series of diastereoisomers of endomorphin-1 (EM1, Tyr(1)-Pro(2)-Trp(3)-Phe(4)-NH(2)) have been synthesized and their potency measured using the guinea pig ileum assay. [D-Phe(4)]EM1 possessed 1/10 the potency of EM1, while potencies of [D-Tyr(1)]EM1 and [D-Trp(3)]EM1 were 50- and 100-fold lower, r...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Paterlini, M G, Avitabile, F, Ostrowski, B G, Ferguson, D M, Portoghese, P S
Format: Artigo
Jezik:Inglês
Izdano: 2000
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300664/
https://ncbi.nlm.nih.gov/pubmed/10653774
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki