Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

Opioid peptide analogs consisting entirely of aromatic amino acid residues and containing conformationally restricted phenylalanine derivatives in position 2 of the peptide sequence were synthesized and pharmacologically characterized in vitro. Both diastereoisomers of H-Tyr-(D or L)-NMePhe-Phe-Phe-...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Schiller, P W, Nguyen, T M, Weltrowska, G, Wilkes, B C, Marsden, B J, Lemieux, C, Chung, N N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1334552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.24.11871
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