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Isoform-specific lidocaine block of sodium channels explained by differences in gating.

When depolarized from typical resting membrane potentials (V(rest) approximately -90 mV), cardiac sodium (Na) currents are more sensitive to local anesthetics than brain or skeletal muscle Na currents. When expressed in Xenopus oocytes, lidocaine block of hH1 (human cardiac) Na current greatly excee...

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Bibliografiske detaljer
Main Authors: Nuss, H B, Kambouris, N G, Marbán, E, Tomaselli, G F, Balser, J R
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300630/
https://ncbi.nlm.nih.gov/pubmed/10620286
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