Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.

Time- and voltage-dependent local anesthetic effects on sodium (Na) currents are generally interpreted using modulated receptor models that require formation of drug-associated nonconducting states with high affinity for the inactivated channel. The availability of inactivation-deficient Na channels...

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Detalhes bibliográficos
Main Authors: Balser, J R, Nuss, H B, Orias, D W, Johns, D C, Marban, E, Tomaselli, G F, Lawrence, J H
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507755/
https://ncbi.nlm.nih.gov/pubmed/8981936
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