Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation.

The intracellular linker between domains III and IV of the voltage-gated Na channel mediates fast inactivation. Targeted alteration of one or more of a triplet of hydrophobic amino acids within this linker region results in a marked slowing in the decay of ionic current. The mechanism of this defect...

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Detalhes bibliográficos
Main Authors: Lawrence, J H, Orias, D W, Balser, J R, Nuss, H B, Tomaselli, G F, O'Rourke, B, Marban, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1233596/
https://ncbi.nlm.nih.gov/pubmed/8874003
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