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VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α
Hypoxia-inducible factor (HIF)-1α is a short-lived protein and is ubiquitinated and degraded through the von Hippel–Lindau protein (pVHL)–E3 ubiquitin ligase pathway at normoxia. Deubiquitination, by reversing ubiquitination, has been recognized as an important regulatory step in ubiquitination-rela...
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| Asıl Yazarlar: | , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1299287/ https://ncbi.nlm.nih.gov/pubmed/15776016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400377 |
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