SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

The SIR2 (silent information regulator 2) gene family has diverse functions in yeast including gene silencing, DNA repair, cell-cycle progression, and chromosome fidelity in meiosis and aging. Human homologues, termed sirtuins, are highly conserved but are of unknown function. We previously identifi...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Onyango, Patrick, Celic, Ivana, McCaffery, J. Michael, Boeke, Jef D., Feinberg, Andrew P.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2002
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129731/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12374852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222538099
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