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SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

The SIR2 (silent information regulator 2) gene family has diverse functions in yeast including gene silencing, DNA repair, cell-cycle progression, and chromosome fidelity in meiosis and aging. Human homologues, termed sirtuins, are highly conserved but are of unknown function. We previously identifi...

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Bibliografske podrobnosti
Main Authors: Onyango, Patrick, Celic, Ivana, McCaffery, J. Michael, Boeke, Jef D., Feinberg, Andrew P.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC129731/
https://ncbi.nlm.nih.gov/pubmed/12374852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222538099
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