Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, is an important participant in signaling pathways that activate T cells. It is the target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. These drugs bind proteins known as cyclophilin (Cyp) and FK506-binding...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
|---|---|
| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2002
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12357034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212504399 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|