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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, is an important participant in signaling pathways that activate T cells. It is the target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. These drugs bind proteins known as cyclophilin (Cyp) and FK506-binding...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2002
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129706/ https://ncbi.nlm.nih.gov/pubmed/12357034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212504399 |
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