Conformational Heterogeneity of Cyclosporin A in Cyclophilin 18 Binding.
The immunosuppressive drug cyclosporin A (CsA) binds to its receptor protein cyclophilin 18 (Cyp18) in two distinct kinetic phases, while the mechanism remains elusive. Stopped-flow measurements coupled with titration and competition experiments were used to investigate the puzzling two-phase proces...
Zapisane w:
| Główni autorzy: | , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2016-01-01
|
| Seria: | PLoS ONE |
| Dostęp online: | http://europepmc.org/articles/PMC4833397?pdf=render |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|