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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, is an important participant in signaling pathways that activate T cells. It is the target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. These drugs bind proteins known as cyclophilin (Cyp) and FK506-binding...

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Detalhes bibliográficos
Main Authors: Jin, Lei, Harrison, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129706/
https://ncbi.nlm.nih.gov/pubmed/12357034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212504399
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