Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes

Histone deacetylases (HDACs) are thought to function as critical mediators of transcriptional repression. However, the physiological targets and posttranslational modifications of the class II HDACs are largely unknown. Here we show that the C terminus of HDAC 6 is both necessary and sufficient for...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hook, Sara S., Orian, Amir, Cowley, Shaun M., Eisenman, Robert N.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12354939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.172511699
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