Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes
Histone deacetylases (HDACs) are thought to function as critical mediators of transcriptional repression. However, the physiological targets and posttranslational modifications of the class II HDACs are largely unknown. Here we show that the C terminus of HDAC 6 is both necessary and sufficient for...
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| Опубліковано в:: | Proc Natl Acad Sci U S A |
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| Автори: | , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
2002
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12354939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.172511699 |
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