Computationally Guided Design, Synthesis, and Evaluation of Novel Non-Hydroxamic Histone Deacetylase Inhibitors, Based on <i>N</i>-Trifluoroacetamide as a Zinc-Binding Group, Against Breast Cancer

<b>Background</b>: Histone deacetylases (HDACs) are enzymes that deacetylate histone proteins, impacting the transcriptional repression and activation of cancer-associated genes such as P53 and Ras. The overexpression of HDACs in breast cancer (BC) underscores their significance as therapeutic targe...

詳細記述

書誌詳細

主要な著者:	Gerardo Morales-Herrejón, Juan Benjamín García-Vázquez, Cynthia Fernández-Pomares, Norbert Bakalara, José Correa-Basurto, Humberto L. Mendoza-Figueroa
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2025-02-01
シリーズ:	Pharmaceuticals
主題:	histone deacetylases HDAC inhibitors hydroxamic acid zinc binding group molecular docking ADMET
オンライン･アクセス:	https://www.mdpi.com/1424-8247/18/3/351
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!