Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4

Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the molecular determinants and kinetics of the molecular recognition of TZD ligands by HDAC4. For this purpose, a structure acti...

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Auteurs principaux:	Markus Schweipert, Niklas Jänsch, Neha Upadhyay, Kalpana Tilekar, Ewelina Wozny, Sidra Basheer, Eva Wurster, Marlene Müller, Ramaa C S, Franz-Josef Meyer-Almes
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-10-01
Collection:	Pharmaceuticals
Sujets:	Human Histone Deacetylase 4 (HDAC4) thiazolidinediones binding mechanism mutational study
Accès en ligne:	https://www.mdpi.com/1424-8247/14/10/1032
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