In vitro characterization of the catalytic domain of human histone deacetylase 5

Abstract Both histone acetyltransferases (HATs) and histone deacetylases (HDACs) control the acetylation state of conserved lysine residues in histone tails. Thereby, modulating chromatin structure and gene transcription. Disturbance of this precisely balanced acetylation state contributes to neuron...

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Autores principales:	Christian Mammen, Fenja M. Hornung, Christian Anzenhofer, Julia Schumacher, Jens Reiners, Jingyu Li, Flaminia Mazzone, Florestan L. Bilsing, Matthias U. Kassack, Thomas Kurz, Sander H. J. Smits
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Scientific Reports
Materias:	HDAC HDACi Histone Catalytic domain Histone deacetylase
Acceso en línea:	https://doi.org/10.1038/s41598-026-37633-5
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