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Computationally Guided Design, Synthesis, and Evaluation of Novel Non-Hydroxamic Histone Deacetylase Inhibitors, Based on <i>N</i>-Trifluoroacetamide as a Zinc-Binding Group, Against Breast Cancer

<b>Background</b>: Histone deacetylases (HDACs) are enzymes that deacetylate histone proteins, impacting the transcriptional repression and activation of cancer-associated genes such as P53 and Ras. The overexpression of HDACs in breast cancer (BC) underscores their significance as therapeutic targe...

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Principais autores: Gerardo Morales-Herrejón, Juan Benjamín García-Vázquez, Cynthia Fernández-Pomares, Norbert Bakalara, José Correa-Basurto, Humberto L. Mendoza-Figueroa
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-02-01
Serier:Pharmaceuticals
Fag:
histone deacetylases
HDAC inhibitors
hydroxamic acid
zinc binding group
molecular docking
ADMET
Online adgang:https://www.mdpi.com/1424-8247/18/3/351
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