Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

von Willebrand factor (VWF) is synthesized primarily in vascular endothelial cells and secreted into the plasma as unusually large VWF multimers. Normally, these multimers are quickly degraded into smaller forms by a plasma metalloproteinase, VWF-cleaving protease (VWF-CP). Decreases in the activity...

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Bibliografski detalji
Glavni autori: Kokame, Koichi, Matsumoto, Masanori, Soejima, Kenji, Yagi, Hideo, Ishizashi, Hiromichi, Funato, Masahisa, Tamai, Hiroshi, Konno, Mutsuko, Kamide, Kei, Kawano, Yuhei, Miyata, Toshiyuki, Fujimura, Yoshihiro
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC129366/
https://ncbi.nlm.nih.gov/pubmed/12181489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172277399
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