Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

von Willebrand factor (VWF) is synthesized primarily in vascular endothelial cells and secreted into the plasma as unusually large VWF multimers. Normally, these multimers are quickly degraded into smaller forms by a plasma metalloproteinase, VWF-cleaving protease (VWF-CP). Decreases in the activity...

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Detalles Bibliográficos
Autores principales: Kokame, Koichi, Matsumoto, Masanori, Soejima, Kenji, Yagi, Hideo, Ishizashi, Hiromichi, Funato, Masahisa, Tamai, Hiroshi, Konno, Mutsuko, Kamide, Kei, Kawano, Yuhei, Miyata, Toshiyuki, Fujimura, Yoshihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC129366/
https://ncbi.nlm.nih.gov/pubmed/12181489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172277399
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