Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

von Willebrand factor (VWF) is synthesized primarily in vascular endothelial cells and secreted into the plasma as unusually large VWF multimers. Normally, these multimers are quickly degraded into smaller forms by a plasma metalloproteinase, VWF-cleaving protease (VWF-CP). Decreases in the activity...

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Bibliographische Detailangaben
Hauptverfasser: Kokame, Koichi, Matsumoto, Masanori, Soejima, Kenji, Yagi, Hideo, Ishizashi, Hiromichi, Funato, Masahisa, Tamai, Hiroshi, Konno, Mutsuko, Kamide, Kei, Kawano, Yuhei, Miyata, Toshiyuki, Fujimura, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129366/
https://ncbi.nlm.nih.gov/pubmed/12181489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172277399
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