Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

von Willebrand factor (VWF) is synthesized primarily in vascular endothelial cells and secreted into the plasma as unusually large VWF multimers. Normally, these multimers are quickly degraded into smaller forms by a plasma metalloproteinase, VWF-cleaving protease (VWF-CP). Decreases in the activity...

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Detalhes bibliográficos
Main Authors: Kokame, Koichi, Matsumoto, Masanori, Soejima, Kenji, Yagi, Hideo, Ishizashi, Hiromichi, Funato, Masahisa, Tamai, Hiroshi, Konno, Mutsuko, Kamide, Kei, Kawano, Yuhei, Miyata, Toshiyuki, Fujimura, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129366/
https://ncbi.nlm.nih.gov/pubmed/12181489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172277399
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