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Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation
In Huntington's Disease and related expanded CAG repeat diseases, a polyglutamine [poly(Gln)] sequence containing 36 repeats in the corresponding disease protein is benign, whereas a sequence with only 2–3 additional glutamines is associated with disease risk. Above this threshold range, longer...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129363/ https://ncbi.nlm.nih.gov/pubmed/12186976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182276099 |
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