Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates

We have examined the kinetics of processing of the HIV-1 Gag-Pro-Pol precursor in an in vitro assay with mature protease added in trans. The processing sites were cleaved at different rates to produce distinct intermediates. The initial cleavage occurred at the p2/NC site. Intermediate cleavages occ...

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Main Authors: Pettit, Steve C, Lindquist, Jeffrey N, Kaplan, Andrew H, Swanstrom, Ronald
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
Assuntos:
Short Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291402/
https://ncbi.nlm.nih.gov/pubmed/16262906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-2-66
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