Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage

Werner syndrome, caused by mutations of the WRN gene, mimics many changes of normal aging. Although roles for WRN protein in DNA replication, recombination, and telomere maintenance have been suggested, the pathology of rapidly dividing cells is not a feature of Werner syndrome. To identify cellular...

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Hlavní autoři: Szekely, Anna M., Bleichert, Franziska, Nümann, Astrid, Van Komen, Stephen, Manasanch, Elisabeth, Ben Nasr, Abdelhakim, Canaan, Allon, Weissman, Sherman M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291253/
https://ncbi.nlm.nih.gov/pubmed/16287861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10492-10506.2005
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